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The influence of El Niño–Southern Oscillation (ENSO) in the Asian monsoon region can persist through the post-ENSO summer, after the sea surface temperature (SST) anomalies in the tropical Pacific have dissipated. The long persistence of coherent post-ENSO anomalies is caused by a positive feedback due to interbasin ocean–atmospheric coupling, known as the Indo-western Pacific Ocean capacitor (IPOC) effect, although the feedback mechanism itself does not necessarily rely on the antecedence of ENSO events, suggesting the potential for substantial internal variability independent of ENSO. To investigate the respective role of ENSO forcing and non-ENSO internal variability, we conduct ensemble “forecast” experiments with a full-physics, globally coupled atmosphere–ocean model initialized from a multidecadal tropical Pacific pacemaker simulation. The leading mode of internal variability as represented by the forecast-ensemble spread resembles the post-ENSO IPOC, despite the absence of antecedent ENSO forcing by design. The persistent atmospheric and oceanic anomalies in the leading mode highlight the positive feedback mechanism in the internal variability. The large sample size afforded by the ensemble spread allows us to identify robust non-ENSO precursors of summer IPOC variability, including a cool SST patch over the tropical northwestern Pacific, a warming patch in the tropical North Atlantic, and downwelling oceanic Rossby waves in the tropical Indian Ocean south of the equator. The pathways by which the precursors develop into the summer IPOC mode and the implications for improved predictability are discussed.

 

Nature has long been a dominant source of inspiration in the area of chemistry, serving as prototypes for the design of materials with proficient performance. In this Feature article, we present our efforts to explore porous organic polymers (POPs) as a platform for the construction of biomimetic materials to enable new technologies to achieve efficient conversions and molecular recognition. For each aspect, we first present the chemical basis of nature, followed by depicting the principles and design strategies involved for functionalizing POPs along with a summary of critical requirements for materials, culminating in a demonstration of unique features of POPs. Our endeavours in using POPs to address the fundamental scientific problems related to biomimetic catalysis and adsorption are then illustrated to show their enormous potential and capabilities for applications ranging from concerted catalysis to radionuclide sequestration. To conclude, we present a personal perspective on the challenges and opportunities in this emerging field. 

The inception and development of supramolecular chemistry have provided a vast library of supramolecular structures and materials for improved practice of medicine. In the context of therapeutic delivery, while supramolecular nanostructures offer a wide variety of morphologies as drug carriers for optimized targeting and controlled release, concerns are often raised as to how their morphological stability and structural integrity impact their in vivo performance. After intravenous (i.v.) administration, the intrinsic reversible and dynamic feature of supramolecular assemblies may lead them to dissociate upon plasma dilution to a concentration below their critical micellization concentration (CMC). As such, CMC represents an important characteristic for supramolecular biomaterials design, but its pharmaceutical role remains elusive. Here, we report the design of a series of self-assembling prodrugs (SAPDs) that spontaneously associate in aqueous solution into supramolecular polymers (SPs) with varying CMCs. Two hydrophobic camptothecin (CPT) molecules were conjugated onto oligoethylene-glycol (OEG)-decorated segments with various OEG repeat numbers (2, 4, 6, 8). Our studies show that the lower the CMC, the lower the maximum tolerated dose (MTD) in rodents. When administrated at the same dosage of 10 mg/kg (CPT equivalent), SAPD 1, the one with the lowest CMC, shows the best efficacy in tumor suppression. These observations can be explained by the circulation and dissociation of SAPD SPs and the difference in molecular and supramolecular distribution between excretion and organ uptake. We believe these findings offer important insight into the role of supramolecular stability in determining their therapeutic index and in vivo efficacy.

 

Patterned leaf coloration in plants generates remarkable diversity in nature, but the underlying mechanisms remain largely unclear.

Here, usingMedicago truncatulaleaf marking as a model, we show that the classicM. truncatulaleaf anthocyanin spot trait depends on two R2R3 MYB paralogous regulators, RED HEART1 (RH1) and RH2.

RH1 mainly functions as an anthocyanin biosynthesis activator that specifically determines leaf marking formation depending on its C‐terminal activation motif. RH1 physically interacts with theM. truncatulabHLH protein MtTT8 and the WDR family member MtWD40‐1, and this interaction facilitates RH1 function in leaf anthocyanin marking formation. RH2 has lost transcriptional activation activity, due to a divergent C‐terminal domain, but retains the ability to interact with the same partners, MtTT8 and MtWD40‐1, as RH1, thereby acting as a competitor in the regulatory complex and exerting opposite effects. Moreover, our results demonstrate that RH1 can activate its own expression and that RH2‐mediated competition can repressRH1expression.

Our findings reveal the molecular mechanism of the antagonistic gene paralogs RH1 and RH2 in determining anthocyanin leaf markings inM. truncatula, providing a multidimensional paralogous–antagonistic regulatory paradigm for fine‐tuning patterned pigmentation.